When fly season hits, every horse owner knows the frustration of battling mosquitoes, gnats, ticks, and those ever-persistent flies. With so many fly sprays on the market, it can feel overwhelming to choose the right one for your horse's needs. That's why we've put together this ultimate fly spray comparison guide to help you make an informed choice.

Below, you'll find a detailed chart comparing seven popular fly sprays, outlining their active ingredients, what they repel or kill, sweat resistance, and special highlights.

Fly Spray Comparison Chart

We know that not all fly sprays are created equal. Some are designed for long days in the sun and sweat, while others prioritize natural, gentle ingredients. Use this chart as a quick reference to see how these top-rated products stack up side by side.

Product Name Active Ingredients Repels/Kills Sweat/Water Resistant Natural or Chemical Highlights
Pyranha Nulli Fly Repellent Spray Pyrethrins, Piperonyl Butoxide, Permethrin Flies, mosquitoes, gnats, lice, deer ticks Moderate Chemical Ready-to-use; water-based spray; contains coat conditioner
Farnam Endure Sweat-Resistant Fly Spray Cypermethrin, Pyrethrins, Piperonyl Butoxide Flies, gnats, mosquitoes, lice, ticks High (sweat- & weather-resistant) Chemical Features RepeLock® conditioner; extended protection lasts up to 14 days
Fly Bye! Plus Fly Spray Proprietary enzyme-based formula (chemical-free) Repels flies by enzyme action (non-toxic) Moderate Natural Chemical-free, biodegradable, safe around pets and people
Pyranha Wipe N' Spray Pyrethrins, Piperonyl Butoxide, Butoxypropyldimethylamine Cyclohexane Flies, gnats, mosquitoes, ticks, fleas High (oily base) Chemical Oil-based formula with coat conditioner; long-lasting
UltraShield EX Fly Spray Cypermethrin, Pyrethrins, Piperonyl Butoxide Flies, mosquitoes, lice, gnats High (sweat- & weather-resistant) Chemical All-weather, water-resistant; includes sunscreens and coat conditioners; 17-day protection
Equiderma Neem & Aloe Herbal Fly Repellent Neem oil, citronella, aloe, other essential oils Flies, ticks, mosquitoes, gnats Moderate Natural All-natural oils; non-toxic; botanical-based soothing scent
Pyranha Legacy Fly Repellent Spray Cypermethrin, Piperonyl Butoxide, Pyrethrins Flies, gnats, mosquitoes, ticks High (oil-based) Chemical Oil-based, weather-resistant; long-lasting; contains coat conditioners

Best Fly Spray

Choosing the Best Fly Spray for Your Horse

With so many options on the table, it helps to break things down by category. Here’s a quick guide to help you narrow in on the best fly spray for your horse based on your needs and priorities.

Best Overall Fly Spray for Horses

  • Pyranha® Wipe N' Spray is the best overall fly spray for horses because it offers long-lasting protection, kills on contact, and leaves a coat-conditioning shine.

Best for Fly Spray Sweat Resistance

Best Natural Fly Spray

Fly Spray With the Longest Lasting Protection

Best Fly Spray for Sensitive Skin

Best Fly Spray With Added Coat Conditioning

Selecting the right fly spray isn't just about repelling pests – it's about matching the product to your horse's specific needs, activity level, and environment. Whether you lean towards chemical formulas for maximum durability or natural options for gentle, eco-friendly care, this guide will help you navigate the choices confidently.